Fibroblast growth factor 23 and cerebrovascular diseases / 国际脑血管病杂志

Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that plays a central role in the regulation of calcium, phosphorus and active vitamin D levels. Recent studies have shown that high FGF23 is associated with cardiocerebrovascular diseases. This article reviews the correlation between FGF23 and cerebrovascular diseases.

Incidence, prevalence and risk factors of post-stroke dementia / 国际脑血管病杂志

Post-stroke dementia (PSD) includes all types of dementia after stroke, which may be the result of cumulative effects of cerebrovascular disease, Alzheimer's disease, and white matter changes. The incidence and prevalence of PSD are high. Its risk factors are mainly vascular risk factors, such as hypertension, atrial fibrillation, and diabetes. Other risk factors also include various imaging phenotypes of cerebrovascular disease, such as white matter hyperintensities, cerebral microbleeds, and brain atrophy. The clinical evaluation of PSD should be conducted at least 3-6 months after the onset of stroke. The prevention of PSD should focus on controlling vascular risk factors and preventing stroke.

Study on the value of CDIO combined with cluster training mode in clinical teaching of cardiopulmonary resuscitation / 中华医学教育探索杂志

Objective:To explore the value of "conceive, design, implement, and operation" (CDIO) combined with cluster training mode in clinical teaching of cardiopulmonary resuscitation (CPR).Methods:A total of 108 interns of General Hospital of Southern Theater Command from January 2019 to November 2020 were included in the study, and they were randomly divided into control group ( n=54) and observation group ( n=54). The control group used the cluster training mode for CPR teaching, and the observation group used CDIO combined with the cluster training mode for CPR teaching. The theoretical performance, operation performance, comprehensive ability, chest compression quality and CPR time of the two groups of interns were compared, and the scores of post competency and satisfaction of the two groups of interns were evaluated. SPSS 22.0 was used for t test and chi-square test. Results:The scores of theory, operation and comprehensive ability in the observation group were higher than those in the control group. Compared with those before training, the compression depth, compression frequency and chest rebound rate of the observation group were higher than those of the control group. The observation group found that the patients' unconscious judgment of pulse free time, the time from the occurrence of ventricular fibrillation to the start of automated external defibrillator (AED), and the time to complete AED were lower than those in the control group. The five dimensions of practical ability, critical thinking ability, coordination ability, career development ability, psychological characteristics and the total score of post competency in the observation group were higher than those in the control group ( P < 0.05). The satisfaction of the observation group with the teaching teacher, practice content, practice form and practice effect was higher than that of the control group ( P<0.05). Conclusion:The application of CDIO combined with cluster training in clinical CPR teaching can improve the interns' theoretical performance, operational performance and comprehensive ability, improve the quality of external chest compression and CPR time, make the interns have good communication ability and post competency, and finally improve the interns' satisfaction.

Application of mind mapping model in the teaching of molecular biology / 生物工程学报

Molecular biology is a biology course containing multiple core concepts and complex biological processes, which are organized in a strong logic. In order to help the medical students in college of traditional Chinese medicine (TCM) understand the content of this professional foundation course, we integrated the mind mapping model into the three sessions of teaching this course. First, putting forward teaching questions through a "nine grids analysis" model before the class teaching; second, transforming class teaching through a "six thinking hats" model; third, reviewing teaching content through a "pyramid principle" model, which helps students develop closed-loop thinking skills. The students' understandings to the course content were enhanced by connecting, merging and diverging the relevant knowledge through thinking visualization. According to the questionnaire, 91% of the students believe that the application of mind mapping model is an effective teaching method, which improves the teaching efficiency and effect. Furthermore, 76% of the students deem this method helps them improve their thinking ability and they also try to apply this method to the study process of other courses. Therefore, the application of mind mapping model in teaching plays an important role in fostering students' high-order thinking skills and provides a new approach for college curriculum teaching.

Literature Study on the Use Situation of Acupuncture-moxibustion Operation Standardization / 上海针灸杂志

Twenty-two items of national criteria of acupuncture-moxibustion operation standardization have been issued by the People’s Republic of China. To understand the situation of use of these criteria, the authors analyzed and studied the situation of application of acupuncture-moxibustion criteria in related papers, textbooks and monographs to provide a basis for further establishing and revising the criteria. The results show that people are building awareness of use of acupuncture-moxibustion criteria, and the criteria have gradually been used in more and more papers, textbooks and works.

Medical equipment maintenance management based on PDCA / 医疗卫生装备

The problems of some hospital in medical equipment maintenance management were introduced from the aspects of maintenance time, maintenance record, maintenance service and self maintenance. Some measures were proposed including simplifying maintenance process through PDCA, informatizing maintenance record, cooperating with third-party maintainer and establishing self maintenance team, so that precision and informatized medical equipment management can be realized to maximize the benefit of medical equipment management.

An introduction and analysis of current situation of Canadian acupuncture standards / 国际中医中药杂志

The standardization of acupuncture and moxibustion in Canada is increasingly flouring nowadays:on one hand,acupuncture industry in legislated provinces is in the charge of direct administrative departments and associations of acu-moxi; on the other hand,according to the local situations,relevant regulations have been made,which are concentrated on two aspects-technical and administrative standards.Undoubtedly,Canadian Alliance of Regulatory Bodies for TCM Practitioners and Acupuncturist (CARB),united by each provincial TCM/Acupuncture Administration,is the first step to issue federal standards and establish federal level management institution.However,now the releasing of a fundamental regulatory file is in need of active corporation and publicity from each province and association.Therefore,it shows that the body of standardization in Canada is still not relatively perfect.Through introducing and analyzing the relevant information,the author expects that the readers can know the current development of acupuncture and moxibustion standardization in Canada.

Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity

Benzene, a recognized hematotoxicant and carcinogen, can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity in a cross-sectional study of workers exposed to benzene (250 workers and 140 controls). A total of 1,236 tag SNPs in 149 gene regions of six pathways were included in the analysis. Six gene regions were significant for their association with white blood cell (WBC) counts (MBP, VCAM1, ALOX5, MPO, RAC2, and CRP) based on gene-region (P < 0.05) and SNP analyses (FDR < 0.05). VCAM1 rs3176867, ALOX5 rs7099684, and MPO rs2071409 were the three most significant SNPs. They showed similar effects on WBC subtypes, especially granulocytes, lymphocytes, and monocytes. A 3-SNP block in ALOXE3 (rs7215658, rs9892383, and rs3027208) showed a global association (omnibus P = 0.0008) with WBCs even though the three SNPs were not significant individually. Our study suggests that polymorphisms in innate immunity genes may play a role in benzene-induced hematotoxicity; however, independent replication is necessary.

Role of autophagy in the pathogenesis of ischemic heart disease / 基础医学与临床

Autophagy is induced by a variety of signals during ischemia and reperfusion.Autophagy has been shown to protect cardiac cells and to reduce the cell loss,but it also has been shown that enhanced autophagy contributes to cell death during I/R.

Effect of antidepressant intervention on mood state of at or around the time of radiation therapy / 中华行为医学与脑科学杂志

Objective To explore the effect of antidepressant intervention on mood state of at or around the time of radiation therapy. Methods 62 hospitalized patients with cancer receiving radiotherapy were divided into two groups by the order of the time when they accept the radiotherapy which called intervention group ( antidepressant fluoxetine group) and control group. And the two groups patients filled out Hamilton Anxiety Scale( HAMA )and Hamilton Depression Scale (HAMD) at or around the time of radiation therapy to investigate the effects of fluoxetine on anxiety and depression. Results The scores of HAMA and HAMD showed that there was no differences between the intervention group and the control group before the radiotherapy. There was significant difference during the radiotherapy ( 6.41 ± 2.30 ) vs ( 9.29 ± 5.62 ); ( 8.80 ± 3. 048 ) vs ( 12.22 ± 8.32 ) and two weeks after the end of the radiotherapy ( 4.90 ± 1.71 ) vs ( 12.32 ± 7.24 ); ( 6.83 ± 2.47 ) vs ( 16.09 ± 8.61 ) between antidepressant fluoxetine group and control group(P ＜ 0.05 ). Conclusion More attention should be paid to mental health and antidepressant can alleviate anxiety and depression of the cancer patients'at or around the time of radiotherapy.

Effects of Jinma Tongluo Capsule on Micronucleu s of Mice Marrow Cells / 中药新药与临床药理

Effects of Jinma Tongluo capsule (JT C) on the incidence of micronucleu s of marrow cells in mice with Kunming species were reported. JTC intragastric d osages of 100 mg/kg, 400 mg/kg, 1600 mg/kg (equivalent to 3, 12 and 48 times of the clinical dosage respectively) were given to the mice.Twenty-four hours later th e mice were e xecuted and the marrow cells were examined. The incidence of micronucleus was 2 .00‰, 1.83‰, 2.17‰ respectively. In the group of dosage of 1600 mg/kg, the inci dence was maintained in the normal limits within 12～72h. And the differences we r e not significant as compared with the negative group and the solvent control gr oup. It's indicated that ig total alkalin of Flos Daturae under 0.86 mg/kg has no effect on micronucleus of mice marrow cells.

Characteristic Performance of F_1 Hybrid of Jobstears (Coix lacryma-jobi) and C.lacryma-jobi var.friamentacea and Inheritance of Stigma Colour / 中草药

The main characters and peroxidase isozymes of Coix lacryma-jobi L. and C.lacryma-jobi var.friumentacea Makino and their F1 hybrid were analyzed. Results showed that the plant height, area of leaves per plant, growth performance, and photosynthetic characteristic of F1 hybrid all exceedcd its parents. Bands of iso-peroxidase were different between F1 hybrid and itsparents. There were more band s of isoperoxid ase in the C.lacryma-jobi var. friumentacea Makino than in C.lacryma-jobi L..This is the first report to show the inheritance regularity of stigma colour which was controlled by two complementation genes.

Effects of Jinma Tongluo Capsule on Micronucleus of Mice Marrow Cells / 中药新药与临床药理

Effects of Jinma Tongluo capsule (JTC) on the incidence of micronucleus of marrow cells in mice with Kunming species were reported. JTC intragastric dosages of 100 mg/kg, 400 mg/kg, 1600 mg/kg (equivalent to 3, 12 and 48 times of the clinical dosage respectively) were given to the mice.Twenty-four hours later the mice were executed and the marrow cells were examined. The incidence of micronucleus was 2.00‰, 1.83‰, 2.17‰ respectively. In the group of dosage of 1600 mg/kg, the incidence was maintained in the normal limits within 12～72h. And the differences were not significant as compared with the negative group and the solvent control group. It's indicated that ig total alkalin of Flos Daturae under 0.86 mg/kg has no effect on micronucleus of mice marrow cells.